Paul Schimmel Selected Research

Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)

1/2021	Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
1/2018	Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.
7/2017	Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
5/2015	The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
12/2014	Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.
2/2008	Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.
12/2006	Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.
1/2006	Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase.

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Paul Schimmel Research Topics

Disease

9	Neoplasms (Cancer) 03/2015 - 01/2006
4	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2021 - 12/2006
2	Peripheral Nervous System Diseases (PNS Diseases) 07/2017 - 09/2006
2	Starvation 05/2015 - 11/2009
2	Malaria 05/2015 - 02/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 12/2014 - 02/2003
2	Inflammation (Inflammations) 01/2010 - 01/2010
2	Confusion (Bewilderment) 12/2009 - 10/2008
1	Antisynthetase syndrome 01/2021
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2018
1	Thrombocytopenia (Thrombopenia) 01/2018
1	Lung Diseases (Lung Disease) 01/2018
1	Fibrosis (Cirrhosis) 12/2014
1	Heart Diseases (Heart Disease) 12/2014
1	Proteostasis Deficiencies 12/2014
1	Myositis (Idiopathic Inflammatory Myopathies) 07/2014
1	Interstitial Lung Diseases (Interstitial Lung Disease) 07/2014
1	Prostatic Neoplasms (Prostate Cancer) 10/2013
1	Nervous System Diseases (Neurological Disorders) 03/2013
1	Fever (Fevers) 02/2013
1	Carcinogenesis 03/2012
1	Hypoxia (Hypoxemia) 10/2008
1	Neuroblastoma 07/2007
1	Type 2D Charcot-Marie-Tooth disease 09/2006
1	Ataxia (Dyssynergia) 09/2006

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
8	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2021 - 01/2006
7	Ligases (Synthetase)IBA 01/2021 - 07/2007
7	Transfer RNA (tRNA)IBA 01/2021 - 07/2007
3	Serine (L-Serine)FDA Link 01/2018 - 10/2008
3	Glycine-tRNA LigaseIBA 03/2012 - 09/2006
2	AutoantibodiesIBA 01/2021 - 07/2014
2	Ala Transfer RNAIBA 01/2018 - 10/2008
2	Alanine-tRNA LigaseIBA 01/2018 - 09/2006
2	Amino Acids FDA Link 05/2015 - 01/2010
2	halofuginoneIBA 05/2015 - 02/2013
2	febrifugineIBA 05/2015 - 02/2013
2	EnzymesIBA 03/2012 - 09/2006
2	Alanine (L-Alanine)FDA Link 12/2009 - 10/2008
1	Thrombopoietin (c-mpl Ligand)IBA 01/2018
1	Tyrosine-tRNA LigaseIBA 01/2018
1	Antimalarials (Antimalarial Agents)IBA 05/2015
1	prolyl T RNA synthetaseIBA 05/2015
1	ResveratrolIBA 03/2015
1	Protein AggregatesIBA 12/2014
1	Histidine-tRNA LigaseIBA 07/2014
1	EpitopesIBA 07/2014
1	AntibodiesIBA 07/2014
1	Messenger RNA (mRNA)IBA 10/2013
1	Phosphotransferases (Kinase)IBA 04/2012
1	DNA (Deoxyribonucleic Acid)IBA 04/2012
1	Adenosine Monophosphate (AMP)IBA 04/2012
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 04/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2012
1	Cadherins (E-Cadherin)IBA 03/2012
1	K cadherinIBA 03/2012
1	Fas Ligand Protein (Fas Ligand)IBA 03/2012
1	Folic Acid (Vitamin M)FDA LinkGeneric 11/2009
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/2008
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2008
1	matrigelIBA 02/2008
1	CytokinesIBA 02/2008

Therapy/Procedure

2	Therapeutics 01/2018 - 01/2006
1	Hematopoietic Stem Cell Transplantation 01/2018